What if a simple yeast, scraped from the peel of tropical fruit during a cholera epidemic, could change the way we protect our microbiome?  In the 1920s, French microbiologist Henri Boulard stumbled upon a probiotic unlike any other. Saccharomyces boulardii isn’t a bacteria, but a hardy yeast that survives heat, stomach acid, and bile. Today, it’s one of the best-studied tools for preventing antibiotic-associated diarrhea, treating traveler’s diarrhea, and protecting gut health when illness strikes.  In this episode of Tribulations, Dr. Ravi Kumar takes you on a journey that weaves history, science, and practical medicine. You’ll discover: The remarkable story of how Boulard’s curiosity led him from alcohol fermentation to a lifesaving probiotic during a cholera outbreak.Why Saccharomyces boulardii acts as a “shepherd” in the gut, preserving balance while pushing back against harmful bacteria.Clinical trial evidence showing its effectiveness against antibiotic-associated diarrhea, traveler’s diarrhea, and recurrent C. difficile infection.Practical dosing strategies for adults and children—when to use it, how long to continue, and important safety caveats.Why a $15 supplement sometimes outperforms prescriptions in protecting your microbiome.It’s a story of serendipity, science, and a forgotten yeast that still holds lessons for modern medicine. For references: drkumardiscovery.com/podcast Stay Connected Podcast signup: drkumardiscovery.com/podcast-signup Instagram: @thedrkumardiscovery Facebook: The Dr Kumar Discovery